石河子地区近十年结肠镜成人结直肠癌及腺瘤检出情况的横断面调查

目的　调查石河子地区近十年结肠镜下成人结直肠癌（colorectal cancer，CRC）、结直肠腺瘤和进展期腺瘤检出率的变化趋势。方法　2010年1月1日—2019年12月31日期间，就诊于石河子大学医学院第一附属医院完成结肠镜检查的病例纳入调查，通过查阅电子病历系统收集病历资料，具体信息包括患者年龄、性别及结直肠腺瘤或CRC的部位、数量、大小和病理类型等。主要观察结直肠腺瘤、结直肠进展期腺瘤和CRC的检出率，包括10年总体检出率以及前五年（2010—2014年）总体检出率和后五年（2015—2019年）总体检出率。结果　共纳入50 645例，经排除标准排除14 931例，最终共35 714例纳入数据分析。结直肠腺瘤、结直肠进展期腺瘤和CRC的10年总体检出率分别为17.65%（6 302/35 714）、4.45%（1 589/35 714）和3.71%（1 324/35 714）。结直肠腺瘤后五年总体检出率［20.33%（4 565/22 457）］高于前五年［13.10%（1 737/13 257）］；结直肠进展期腺瘤后五年总体检出率［4.69%（1 053/22 457）］高于前五年［4.04%（536/13 257）］；CRC后五年总体检出率［3.30%（741/22 457）］低于前五年［4.40%（583/13 257）］。结论　石河子地区2015—2019年结直肠腺瘤检出率较2010—2014年有较大幅度升高，结直肠进展期腺瘤检出率较2010—2014年有小幅升高，而CRC检出率较2010—2014年有小幅下降，由此推测结肠镜检查发现并切除结直肠腺瘤对降低CRC发病率可能具有重要作用。     

Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression

Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function extensively in numerous physiological and pathological processes. Small nucleolar RNA host gene 3 (SNHG3) is a novel lncRNA and has been reported to be differentially expressed in various tumors, such as liver cancer, gastric cancer, and glioma. However, the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly understood. In this review, we summarize the results of SNHG3 studies in humans, animal models, and cells to underline the expression and role of SNHG3 in cancer. SNHG3 expression is upregulated in most tumors and is detrimental to patient prognosis. SNHG3 expression in lung adenocarcinoma remains controversial. Concurrently, SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms, including competing endogenous RNA effects. A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment.     

Experimental study on the biocompatibility and osteogenesis induction ability of PLLA/DDM scaffolds

Odontology - To investigate the characterization and function of a novel porous osteogenic material (PLLA / DDM) containing polylactic acid and demineralized dentin matrix. The surface morphology...     

Survival after minimally invasive vs. open radical nephrectomy for stage I and II renal cell carcinoma

International Journal of Clinical Oncology - A recently reported phase III randomized trial comparing open and minimally invasive hysterectomy showed significantly higher rates of local recurrence...